人/狗/大鼠/小鼠 TNNT2 重组蛋白

GR119068   Genorise recombinant human troponin T (TNNT2) protein


Cardiac Troponin T (TnT), is a protein which in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles ａnd regulates muscle contraction in response to alterations in intracellular calcium ion concentration.

s part of the Troponin complex, the function of cTnT is to regulate muscle contraction. The N-terminal region of TnT that strongly binds actin most likely moves with Tm and actin during strongmyosin crossbridge binding ａnd force generation. This region is likely involved in the transduction of cooperativity down the thin filament. The C-terminal region of TnT constitutes part of the globular troponin complex domain, ａnd participates in employing the calcium sensitivity of strongmyosin crossbridge binding to the thin filament.