技术文章库
Exalpha Biologicals produces and sells products for Life Science Research, including monoclonal and polyclonal antibodies, for use in immunohistochemistry, western blot, ELISA and Flow Cytometry. We offer over 800 products and, through collaborations with other scientists as well as our own in-house R&D programs, Exalpha continues to bring leading edge products to market. Our family of CD antibodies combines quality and performance with reasonable prices to make our CD antibodies the best value in the market today. Our family of Proliferation products offer easy all-in-one kits or stand alone antibodies to quantitate proliferating cells. Take a look at our website or call us for additional information.
Background
CD: cluster designation of monoclonal antibodies (clusters of differentiation)
The last conference was in 2000. The next conference is in 2004.
For 1st to 6th workshops, antibodies were submitted to the organizing laboratory, coded and sent to participating laboratories for testing against various cell types. For the 7th workshop, a CD designation could be established for a molecule if its gene has been cloned and at least one specific monoclonal antibody had been studied in the Workshop
CD1
Family of non-polymorphic MHC class I-like glycoproteins
On chromosome 1q22-23 (not MHC linked)
Function: restrict T cell responses to certain antigens; may mediate thymic T cell development
Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis
CD1a
Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders
Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells)
Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis
References: AJSP 2001;25:630
CD1b
Negative staining: normal B cells
