merck 559389-1MG SB 203580（sb203580,sb-203580）

SB 203580

产品说明:SB203580也写作SB 203580或SB-203580，是一种常用的p38 MAPKYZ剂。SB203580可以通透细胞，YZp38 MAPK（p38 MAP kinase），YZ后续MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通过YZp38 MAPK，SB203580可以有效YZ一些炎症因子（如IL-1β、TNF-α）诱导的部分信号转导。SB203580选择性YZp38 MAPK，IC50为600 nM；对于JNK/SAPK和p44/42 MAPK（即Erk1/2）无显著的YZ作用，IC50仅为100 μM。
     SB203580分子量为377.43，分子式为C₂₁H₁₆N₃FOS，CAS Number：152121-47-6。    

MERCK相关产品资料：

559389  SB 203580 （ SB 203580 ）

4-（4-Fluorophenyl）-2-（4-methylsulfinylphenyl）-5-（4-pyridyl）1H-imidazole

A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase （IC₅₀ = 34 nM in vitro, 600 nM in cells）. Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 （IC₅₀ = 50-100 nM）. Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits plaet aggregation caused by collagen （IC₅₀ = 0.2-1.0 µM） or the thromboxane analog U-46619 （Cat. No. 538944）. A 1 mg/ml solution of SB 203580 （Cat. No. 559398） in anhydrous DMSO is also available.