W140 (trifluoroacetate salt)

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产品名称：W140 (trifluoroacetate salt)

产品别名：{(3S)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphonic acid trifluoroacetate (1:1)

CAS号：909725-64-0

英文别名：{(3S)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphonic acid trifluoroacetate (1:1)

分子量：456.4

分子式：C₁₆H₂₇N₂O₄P • CF₃COOH

纯度：≥95%

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保存方法：Store at -20℃

描述：Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.^1,2,3 It exerts its activity by binding to five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8.^1,2 W140 is an inactive enantiomer of W146, a selective S1P₁ antagonist (K_i = 77 nM), that binds to the S1P₁ receptor with a K_i of 4.6 µM (2a = W146; 2b = W140 in supplemental material).⁴ It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

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