W140 trifluoroacetate salt,

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试剂描述：

产品名称：W140 trifluoroacetate salt

产品别名：

CAS号：见爱必信官网

英文别名：

分子量：456.4

分子式：C₁₆H₂₇N₂O₄P•C₂F₃HO₂

纯度：见爱必信官网

外观：A crystalline solid

保存方法：Store at -20° C

描述：Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 (trifluoroacetate salt) is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

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