5(S),6(R)-7-trihydroxymethyl Heptanoate,Methyl (5S,6R)-5,6,7-trihydroxyheptanoate,78606-80-1

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产品名称：5(S),6(R)-7-trihydroxymethyl Heptanoate

产品别名：5(S),6(R),7-Trihydroxyheptanoic acid methyl ester

CAS号：78606-80-1

英文别名：5(S),6(R),7-Trihydroxyheptanoic acid methyl ester

分子量：192.2

分子式：C₈H₁₆O₅

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保存方法：Store at -20° C

描述：Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid by an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP). 5(S),6(R)-7-trihydroxymethyl heptanoate is a C-7 truncated analog of LXA4 that is equiactive as LXA4 in inhibition of LTB4-induced PMN chemotaxis with an IC₅₀ of 5nM.

应用：A potent lipoxin A4 agonist

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