| 规格： | 1mg | 产品价格： | ￥585.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2639.0 |
| 规格： | 10mg | 产品价格： | ￥4680.0 |
| CAS号 | 78606-80-1 | ||
| 别名 | BML-111 | ||
| 分子式 | C8H16O5 | 分子量 | 192.2 |
| 溶解性 | Soluble in DMSO | 储存条件 | Store at -20° |
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| References: | |
5(S), 6(R)-7-trihydroxymethyl Heptanoate is a C-7 truncated analog of lipoxin A4 (LXA4). 5(S), 6(R)-7-trihydroxymethyl Heptanoate shows an inhibitory effect on leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis [1].
Lipoxins (LXs) are trihydroxy tetraene metabolites endogenously produced anti-inflammatory eicosanoids [2]. Lipoxins were derived from arachidonic acid through an interaction between different lipoxygenases with carbon-15 and carbon-5 to form LXA 4 and LXB 4 [1]. LXs functioned as endogenous “braking signals” in inflammation [2]. LXs showed diverse bioactions on individual leukocytes, stimulating the activation of monocytes and macrophages, inhibiting the activation of PMNs, eosinophils, and lymphocytes [2].
5(S),6(R)-7-trihydroxymethyl Heptanoate inhibited leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis with an IC50 value of 5 nM, which was equiactive as LXA4 [1].
References:
[1] Lee T H, Lympany P, Crea A E G, et al. Inhibition of leukotriene B 4-induced neutrophil migration by lipoxin A 4: structure-function relationships[J]. Biochemical and biophysical research communications, 1991, 180(3): 1416-1421.
[2] McMahon B, Godson C. Lipoxins: endogenous regulators of inflammation[J]. American Journal of Physiology-Renal Physiology, 2004, 286(2): F189-F201.
