分子量：
24784 Da
细胞定位：
Antigen Cellular Localization:Isoform 1: Cytoplasm. Nucleus.
形式：
Liquid
参考文献：
Zou Y, Liu Y, Wu X, et al. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J. Cell Physiol. 2006; 208:267-73.Jullien D, Gorlich D, Laemmli UK, et al. Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin α. EMBO J. 1999; 18:4348-58.Park J, Seo T, Kim H, et al. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. Mol. Cell Biol. 2005; 25:8202-14.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality RPA Interacting Protein antibody.
功能：
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
总结：
RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism.
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