NCSTN / Nicastrin Antibody (clone AT3B2)

分子量：
78kDa
细胞定位：
Antigen Cellular Localization:Membrane; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Yu G.,et al.Nature 407:48-54(2000).Clark H.F.,et al.Genome Res. 13:2265-2270(2003).Ota T.,et al.Nat. Genet. 36:40-45(2004).Gregory S.G.,et al.Nature 441:315-321(2006).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality NCSTN / Nicastrin antibody (clone AT3B2).
功能：
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
总结：
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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