分子量：
54kDa
细胞定位：
Antigen Cellular Localization:Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
形式：
Liquid
参考文献：
Macneil D.J.,et al.Biochem. Biophys. Res. Commun. 198:328-334(1994).Lok S.,et al.Gene 140:203-209(1994).Menzel S.,et al.Genomics 20:327-328(1994).Buggy J.J.,et al.Diabetes 46:1400-1405(1997).Ruckert C.,et al.J. Biol. Chem. 281:2306-2316(2006).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality GCGR / Glucagon Receptor antibody (Extracellular Domain).
功能：
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
总结：
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
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