Neurofilament, phospho (NF-H) (Neuronal Marker) Antibody - Without BSA and Azide

分子量：
200kDa
细胞定位：

形式：
Liquid
参考文献：
Debus E., et al. Differentiation 25(2), 193-203 (1983). | Gotow T., et al. J. Neuroscience Res. 37(6), 691-713 (1994). | Berglund A.M., et al. J Comp Neurol. 306(3), 393-408 (1991). | Guadano-Ferraz A., , et al. Develop. Brain Res. GOTOBUTTON BM_4_ 56(2), 244-256, (1990). | Obermann W., et al. Eur. J. Biochem 233, 110-115 (1995). | Marx A., et al. Am. J.Pathol. 148(6), 1839-1850 (1996)
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Neurofilament, phospho (NF-H) (Neuronal Marker) antibody - Without BSA and Azide.
功能：
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
总结：
This MAb reacts with a 200kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase, this Ab no longer binds. Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.
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