分子量：
70-80kDa
细胞定位：
Antigen Cellular Localization:Melanosome membrane; Single-pass type I membrane protein
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129. | Hearing, V.J., et al. 1987. Mammalian tyrosinase—the critical regulatory control point in melanocyte pigmentation. Int. J. Biochem. 19: 1141-1147
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Tyrosinase (Melanoma Marker) antibody.
功能：
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
总结：
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
联系方式：
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