PSAP / Prosaposin Antibody (clone 4D5F4)

分子量：
58kDa
细胞定位：
Antigen Cellular Localization:Lysosome
形式：
Liquid
参考文献：
Rorman E.G.,et al.Genomics 5:486-492(1989).Nakano T.,et al.J. Biochem. 105:152-154(1989).Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Deloukas P.,et al.Nature 429:375-381(2004).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality PSAP / Prosaposin antibody (clone 4D5F4).
功能：
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
总结：
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
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