Product Name alpha-synuclein antibody
Catalog No PAab09891
Packing 100ul
Form liquid
Alternative Name Alpha synuclein, NACP, PARK1, PARK4, SNCA
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Immunogen synuclein, alpha (non A4 component of amyloid precursor)
Specificity Human, Mouse, Rat
Tested Application ELISA, IHC, WB
Recommended dilution WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000
IHC use Immunohistochemistry of paraffin-embedded mouse brain using PAab09891(SNCA antibody) at dilution of 1:1000
WB use
mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab09891(SNCA antibody) at dilution of 1:1000
Protein Information
Gene ID 6622
Uniprot ID P37840
Calculated MW 23 kDa
Research Area Neuroscience
