GSK3A antibody| GSK3A抗体

GSK3A抗体| GSK3A antibody

货号  PAab03672

蛋白别名  

蛋白介绍

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

产品描述

anti-GSK3A antibody is a Rabbit Polyclonal antibody againstGSK3A..

建议稀释比例

IHC

Immunohistochemistry of paraffin-embedded human prostate cancer using PAab03672(GSK3A antibody) at dilution of 1:50

Western blot

human serum tissue were subjected to SDS PAGE followed by western blot with PAab03672(GSK3A antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!)

 

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