HDAC3 antibody| HDAC3抗体

HDAC3抗体| HDAC3 antibody

货号  PAab03798

蛋白别名  

蛋白介绍

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

产品描述

anti-HDAC3 antibody is a Rabbit Polyclonal antibody againstHDAC3..

建议稀释比例

IHC

Immunohistochemistry of paraffin-embedded human ovary tumor using PAab03798(HDAC3 antibody) at dilution of 1:50

Western blot

HL-60 cells were subjected to SDS PAGE followed by western blot with PAab03798( HDAC3 Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!)

 

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