| 品名 | anti- HNRNPK antibody |
| 货号 | FNab03955 |
| 规格 | 100µg |
| 状态 | liquid |
| 纯化方法 | Immunogen affinity purified |
| 纯度 | ≥95% as determined by SDS-PAGE |
| 宿主 | Rabbit |
| 亚型 | IgG |
| 存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
| 背景介绍 | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction(By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21(lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. |
| 免疫原 | heterogeneous nuclear ribonucleoprotein K |
| 别称 | HNRPK |
| 分子量 | 51 kDa |
| Uniprot ID | P61978 |
| 适用种属 | Human, Mouse, Rat |
| 验证应用 | ELISA, WB, IHC, IF, FC, IP |
| 建议稀释比例 |
| 图片 |  | Immunohistochemistry of paraffin-embedded human breast cancer using FNab03955(HNRNPK antibody) at dilution of 1:50 |
 | HeLa cells were subjected to SDS PAGE followed by western blot with FNab03955(HNRNPK antibody) at dilution of 1:300 |
| 注意事项 | HNRNPK antibody|HNRNPK抗体仅供科研使用 |
| 产品链接 | https://www.fn-test.cn/product/FNab03955/ |