品名 | anti- LARGE antibody |
货号 | FNab04697 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide(N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan(DAG1)(PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide(PubMed:25279699). |
免疫原 | like-glycosyltransferase |
别称 | KIAA0609, LARGE1 |
分子量 | 65-70 kDa |
Uniprot ID | O95461 |
适用种属 | Human, Mouse |
验证应用 | ELISA, WB |
建议稀释比例 |
图片 |  |
 | mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab04697( LARGE Antibody) at dilution of 1:1000 |
注意事项 | LARGE antibody|LARGE抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab04697/ |