品Pai:miltenyi，产品名称：CD282 (TLR2)-Biotin,hum & mouse 30 tests
CD282 (TLR2) antibodies, human and mouse - Miltenyi Biotec
货号：130-099-014
Clone REA109 recognises human and mouse CD282, also known as toll-like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type 1 transmembrane proteins with extracellular leucine-rich repeats and intracellular toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram+ and Gram– bacteria, lipoteichoic acid (LTA) in Gram+ bacteria, lipoarabinomannan and lipomannan from Mycoplasma, and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and triacylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial, and epithelial cells.
Additional information: Clone REA109 displays negligible binding to Fc receptors.
| Clone | Isotype |
|---|---|
| REA109 | recombinant human IgG1 |
