MMP-2 Inhibitor II MMP-2的不可逆YZ剂
- 品牌：进口
- 型号：C5818
- 产地：美国
- 供应商：上海恒斐生物科技有限公司
- 供应商报价：¥572
- 标签：MMP-2 Inhibitor II MMP-2的不可逆抑制剂、MMP-2 Inhibitor II MMP-2的不可逆抑制剂价格、MMP-2 Inhibitor II MMP-2的不可逆抑制剂厂家、MMP-2 Inhibitor II、、上海恒斐生物科技有限公司
产品库
| CAS号 | 869577-51-5 | SDF | Download SDF |
| 别名 | Matrix Metalloproteinase-2 Inhibitor II | ||
| 化学名 | N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-methanesulfonamide | ||
| SMILES | CS(NC(C=C1)=CC=C1OC2=CC=C(S(CC3OC3)(=O)=O)C=C2)(=O)=O | ||
| 分子式 | C16H17NO6S2 | 分子量 | 383.4 |
| 溶解性 | Soluble in DMSO | 储存条件 | Store at -20°C |
| 运输条件 | SY装：蓝冰运输。 其他可选规格：常温运输或根据您的要求用蓝冰运输。 | ||
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。 | ||
MMP-2 Inhibitor II is an irreversible, potent and selective MMP-2 inhibitor with Ki value of 2.4 μM [1].
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play important roles in physiological and pathological conditions. Two MMPs, gelatinases A and B (MMP-2 and MMP-9, respectively), is highly expressed in human cancer, and a direct relationship between cancer progression and gelatinase expression and activity has been well established [1].
MMP-2 Inhibitor II, an oxirane p-sulfonamido analog of SB-3CT, is an irreversible, potent and selective MMP-2 inhibitor. MMP-2 Inhibitor II inhibited MMP-2, MMP-1 and -7 with Ki values of 2.4 μM, 45 and 379 μM, respectively, and didn’t inhibit MMP-3, -7, or -9 [1]. In bovine retinal endothelial cells, MMP-2 Inhibitor II reduced glucose-induced increases in the gelatinolytic activity of MMP-2 and mRNA levels of MMP-2 and MT1-MMP. MMP-2 Inhibitor II also inhibited glucose-induced alterations in TIMP-2 and MT1-MMP gene expressions [2]. MMP-2 Inhibitor II had also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation [3].
MMP-2 Inhibitor II MMP-2的不可逆YZ剂References:
[1]. Ikejiri M, Bernardo MM, Bonfil RD, et al. Potent mechanism-based inhibitors for matrix metalloproteinases. J Biol Chem. 2005 Oct 7;280(40):33992-4002.
[2]. Kowluru RA, Kanwar M. Oxidative stress and the development of diabetic retinopathy: contributory role of matrix metalloproteinase-2. Free Radic Biol Med. 2009 Jun 15;46(12):1677-85.
[3]. Xue M, McKelvey K, Shen K, et al. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford). 2014 Dec;53(12):2270-9.
