商品分类：多克隆抗体
产品概述：This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
来源：Goat
存储溶液：0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献：Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.SUMO modification regulates the transcriptional activity of MAML1. Lindberg MJ, et al. FASEB J, 2010 Jul. PMID 20203086.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Hao L, et al. Oncogene, 2010 Jan 14. PMID 19838210.Transcriptional mechanisms by the coregulator MAML1. Saint Just Ribeiro M, et al. Curr Protein Pept Sci, 2009 Dec. PMID 19751190.
特异性：Human
别名：Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632)
简单描述：Goat Polyclonal Goat Anti-MAML1 / Mastermind Antibody. Validated for use in WB, IHC, E.
详情：FunctionActs as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.Cellular_LocationNucleus speckle. Note=Nuclear, in a punctate mannerTissue_LocationWidely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
