商品分类：多克隆抗体
产品概述：Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
靶点/蛋白：15 amino acid peptide from the middle of human precerebellin
来源：Rabbit
参考文献：Urade Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).Ota T.,et al.Nat. Genet. 36:40-45(2004).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Yiangou Y.,et al.J. Neurochem. 53:886-889(1989).
特异性：Human, Mouse, Rat
别名：Cerebellin-1, Precerebellin, Cerebellin, CER, [des-Ser1]-cerebellin, CBLN1
应用：IHC-P (10 μg/ml), WB (2-4 μg/ml),
简单描述：Rabbit Polyclonal CBLN1 / Cerebellin 1 Antibody. Validated for use in WB, IHC-P.
详情：FunctionRequired for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).Cellular_LocationSecreted. Cell junction, synapse, postsynaptic cell membraneTissue_LocationIn the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
