商品分类：多克隆抗体
产品概述：Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important in binding G proteins.1-3 The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3A1AR is widely distributed and has been well characterized. High expression of A1AR is found in brain (mainly in the cortex, cerebellum, and hippocampus), dorsal horn of the spinal cord, adrenal gland, and atria, and to a lower extent in several other tissues including adipose tissue, colon, and kidney.2,4A1AR modulates the activity of several ion channels. Activation of A1AR (by adenosine, its major agonist) inhibits N-type Ca2+ channels via a voltage-dependent, pertussis toxin (PTX)-sensitive pathway in neurons of the rat major pelvic ganglia (MPG).5Since A1AR is the most prominent adenosine receptor in adipocytes, it has become a natural target for research on obesity, which is a major health problem.6,7 A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.8-10
靶点/蛋白：Peptide (C)KKVSASSGDPQKYYGKE, corresponding to amino acid residues 213-229 of human A1AR (Accession P30542). 3rd intracellular loop.
来源：Rabbit
存储溶液：Affinity purified antibody, lyophilized powder
参考文献：1. Okusa, M.D. (2002) Am. J. Physiol. 282, F10.2. Nakata, H. (1989) J. Biol. Chem. 264, 16545.3. Linden, J. (1991) FASEB J. 5, 2668.4. Park, K-S. et al. (2001) J. Pharmacol. Exp. Therap. 299, 501.5. Rice, A.M. et al. (2000) Endocrinology 141, 1442.6. LaNoue, K.F. and Martin, L.F. (1994) FASEB J. 8, 72.7. Synowitz, M. et al. (2006) Cancer Res. 66, 8550.8. Lelievre, V. et al. (1998) Eur. J. Pharmacol. 341, 289.9. Khoo, H.E. et al. (1996) Cancer Lett. 106, 17.
特异性：Human, Mouse, Rat
别名：Adenosine receptor A1, ADORA1
应用：WB~~1:200-1:2000ICC~~1:100
简单描述：Rabbit Polyclonal A1 Adenosine Receptor Antibody. Validated for use in WB, IHC, ICC.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
