商品分类：多克隆抗体
产品概述：G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
靶点/蛋白：Human Glucagon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
来源：Rabbit
参考文献：Macneil D.J.,et al.Biochem. Biophys. Res. Commun. 198:328-334(1994).Lok S.,et al.Gene 140:203-209(1994).Menzel S.,et al.Genomics 20:327-328(1994).Buggy J.J.,et al.Diabetes 46:1400-1405(1997).Ruckert C.,et al.J. Biol. Chem. 281:2306-2316(2006).
特异性：Human
别名：Glucagon receptor, GL-R, GCGR
应用：IHC-P (2-5 μg/ml)
简单描述：Rabbit Polyclonal GCGR / Glucagon Receptor Antibody (N-Terminus). Validated for use in IHC-P.
详情：FunctionG-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.Cellular_LocationCell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
