商品分类：单克隆抗体
产品概述：This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.āDeficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
来源：Mouse
参考文献：Haraguchi, Y., et al. 1991. Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperam- monemia. Gene 107: 335-340. | Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401. | Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003. |
特异性：Human, Dog
别名：Carbamoyl-phosphate synthase [ammonia], mitochondrial, 6.3.4.16, Carbamoyl-phosphate synthetase I, CPSase I, CPS1
简单描述：Mouse Monoclonal CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - Without BSA and Azide. Validated for use in IHC, IF. Clone: CPS1/1022.
详情：FunctionInvolved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.Cellular_LocationMitochondrion. Nucleus, nucleolusTissue_LocationPrimarily in the liver and small intestine.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
