商品分类：单克隆抗体
产品概述：Alpha B Crystallin, first identified as a structural component of the vertebrate eye lens, is expressed at high levels in lens and at lower levels in a number of other tissues, most notably cardiac and skeletal muscle, kidney, and brain (1). It is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease (2). The major phosphorylation site of Alpha B Crystallin in brains of patients with Alexander's disease or Alzheimer's disease as well as in aged controls is Serine 59 (3). Racemization, isomerization, and oxidation of Alpha B Crystallin are said to occur spontaneously in the aging process (4).
靶点/蛋白：A synthetic peptide corresponding to residues on the C terminus of human Alpha B Crystallin was used as an immunogen.
来源：Rabbit
存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：1. Dubin RA, et al. Genomics 7(4):594-601, 1990
2. Iwaki A, et al. Neurosci Lett 140(1):89-92, 1992
3. Kato K, et al. J Neurochem 76(3):730-6, 2001
4. Fujii N, et al. Biochim Biophys Acta 204(2):157-63, 1994
特异性：Human, Rat
别名：Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2
应用：WB~~1:500~2000IHC~~1:100~250
简单描述：Rabbit Monoclonal Crystallin Alpha B Antibody Crystallin. Validated for use in WB, IHC. Clone: EPR2752.
详情：FunctionMay contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.Cellular_LocationCytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing specklesTissue_LocationLens as well as other tissues.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
