商品分类：单克隆抗体
产品概述：Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation.
来源：Mouse
参考文献：McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. | Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995. | Smith JW et al. Interaction of integrins ?v?3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271. | Du XP et al. Ligands activate integrin ?IIb/?3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416. | Law DA et al. Outside-in integrin signal transduction. ?IIb/?3-(GP IIb/IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996, 271(18):10811-10815. | Moroi M and Jung SM. Integrin-mediated platelet adhesion. Front Biosci 1998, 3:D719-728
特异性：Human
别名：Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB
简单描述：Mouse Monoclonal CD41a / Integrin alpha2b (Platelet Marker) Antibody - Without BSA and Azide. Validated for use in IF, FC. Clone: ITGA2B/1036.
详情：FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
