商品分类：单克隆抗体
产品概述：It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
来源：Mouse
存储溶液：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
参考文献：Hudson DL, et. al. Hybridoma, 1992, 11:367-79
特异性：Human, Pig, Dog
别名：Involucrin, IVL
简单描述：Mouse Monoclonal Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide. Validated for use in IHC-P, IF, FC. Clone: SPM259.
详情：FunctionPart of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.Cellular_LocationCytoplasm. Note=Constituent of the scaffolding of the cornified envelopeTissue_LocationKeratinocytes of epidermis and other stratified squamous epithelia
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
