商品分类：单克隆抗体
产品概述：CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.
来源：Mouse
参考文献：Bregni, M. Siena, S., Formosa, A., Lappi, D.A., Martineau, D., Malavasi, F., Dorken, B., Bonadonna, G. and Gianni, A.M. 1989. B cell restricted saporin immunotoxins: activity against B cell lines and chronic lymphocytic leukemia cells. Blood 73: 753-76
特异性：Human, Monkey, Chimpanzee
别名：B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19
简单描述：Mouse Monoclonal CD19 (B-Lymphocyte Marker) Antibody - Without BSA and Azide. Validated for use in IF, FC. Clone: CVID3/429.
详情：FunctionAssembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.Cellular_LocationMembrane; Single-pass type I membrane protein
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
