商品分类：单克隆抗体
产品概述：It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
来源：Mouse
存储溶液：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
参考文献：Garner AP et al. Oncogene 21:8089-104 (2002) | Minemoto Y et al. Exp Cell Res 262:37-48 (2001
特异性：Human, Mouse, Hamster
别名：G2/mitotic-specific cyclin-B1, CCNB1, CCNB
简单描述：Mouse Monoclonal Cyclin B1 (G2- & M-phase Cyclin) Antibody - Without BSA and Azide. Validated for use in IF, FC, IP. Clone: V92.1.
详情：FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition.Cellular_LocationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示：不可用于临床ZL。
