信号通路甲基化PCR芯片 Notch Signaling Pathway EpiTect Methyl qPCR Array Notch

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Notch Signaling Pathway EpiTect Methyl qPCR Array

Notch信号通路甲基化PCR芯片
 

Product	Species	Technology	Cat. No.
Notch Signaling Pathway EpiTect Methyl qPCR Array	Human	DNA Methylation	EAHS-611Z
Notch Signaling Pathway EpiTect Methyl qPCR Array	Mouse	DNA Methylation	EAMM-611Z
Notch Signaling Pathway EpiTect Methyl qPCR Array	Rat	DNA Methylation	EARN-611Z

The Human Notch Signaling Pathway EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes central to Notch signal transduction. The Notch signaling pathway regulates the expression of genes mediating cell-cell communication and developmental processes. DNA methylation status changes on key regulatory genes during development affect their ability to be induced or repressed by Notch and other signaling pathways. Profiling research samples containing genomic DNA from cellular or fresh tissue with this array may help to correlate CpG island methylation status with biological phenotypes such as developmental stages. This array contains key ligands, cofactors, receptors, downstream signaling effectors, and target genes for Notch signaling. The results may also help provide further insights into the molecular mechanisms and biological pathways behind the role of Notch signaling during cellular communication, differentiation, and development. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes central to Notch signal transduction with this DNA methylation PCR array.
The EpiTect Methyl Signature qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease. Both 96-well and 384-well ( 4 X 96 ) formats are available.
The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.
 
 
Notch信号通路甲基化PCR芯片用于研究Notch信号转导通路上的22个核心基因的启动子甲基化状态。Notch信号通路调节基因的表达，介导细胞与细胞之间的通讯和发育过程。在发育过程中关键调控基因的DNA甲基化状态发生变化，影响其被诱导能力或被Notch和其他信号通路YZ。利用这些芯片分析细胞或新鲜组织基因组DNA样本有助于关联CpG岛甲基化状态与生物表型。这个芯片包含重要的配体,辅酶因子、受体、下游信号效应器和Notch信号通路的靶标基因。结果也助于进一步洞察细胞通讯,分化,和发育过程中Notch信号通路角色背后的分子机制和生物学通路。利用这个芯片，通过简单的限制性内切酶消化和实时定量PCR，就可以研究分析Notch信号通路上22个核心基因的启动子甲基化状态。
 
包括96-孔板和384-孔板( 4 X 96 )。
 
Gamma Secretase Complex: NCSTN, PSENEN.
Downstream Signaling: DVL3, NUMBL.
Transcription Factors: RBPJL, SNW1.
Transcriptional Activators / Repressors: CREBBP, CTBP1, HDAC2, KAT2A, MAML1, NCOR2.
Target Genes: CCND1, ERBB2, HES1, NFKB2.