和元腺相关病毒（adeno-associated virus，AAV）是一类细小病毒，基因组为单链DNA，对分裂细胞和非分裂细胞均具有感染能力。 AAV的血清型是指目前已发现的不同衣壳蛋白的数十种AAV在体内产生不同的抗血清类型，它们对相同的组织和细胞具有不同的感染效率。
重组腺相关病毒rAAV是利用AAV2型基因组与不同的衣壳蛋白结合产生的混合体病毒载体，一般标记为rAAV2/N (N为不同的衣壳血清型)。纽恩生物通过长期的研发，构建了一系列用于基因表达和基因干扰操作的载体。
病毒感染实例如下： 2．慢病毒 慢病毒(Lentivirus)： 是一类改造自人免疫缺陷病毒(HIV)的病毒载体。它是一种RNA病毒，可利用逆转录酶将外源基因整合到基因组中实现稳定长时表达。目前广泛用于哺乳动物细胞和整体的基因转化操作，具有能同时感染分裂期与非分裂期的细胞等特性。
病毒感染实例如下： 3. 逆转录病毒 逆转录病毒(Retrovirus) ：改自鼠白血病病毒(MMLV),是一种RNA病毒，可以利用逆转录酶将外源基因整合到基因组中实现稳定长时表达。逆转录病毒特异性地感染分裂细胞，对造血干细胞和神经干细胞在体外和体内感染具有良好的效果。
病毒感染实例如下：
4. 腺病毒 腺病毒 (Adenovirus) ：是一种DNA病毒，具有广泛的细胞和组织感染能力。感染过程剧烈，适于在短时间内进行基因高表达的实验。与其它病毒载体相比，腺病毒ZD优势在于插入片段较长，表达活性强；可进行扩增操作。
病毒感染实例如下：二、客户代表性文章列表[1] Science. (IF=34.661).Li K,et.al.(2013).βCaMKII in lateral habenula mediates core symptoms of depression.[腺相关病毒，神经系统，外侧缰核，干扰]
[2] Science. (IF=34.661).Ding L,et.al.(2014).Medial prefrontal activity during delay period contributes to learning of a working memory task.[腺相关病毒，光敏感，神经系统，前额叶]
[3] Nature Medicine. (IF=30.357).Zhu LJ,et.al.(2014).CAPON-nNOS coupling can serve as a target for developing new anxiolytics.[腺相关病毒，体内注射，过表达]
[4] Nature Medicine. (IF=30.357).Cao X,et.al.(2013).Astrocyte-derived ATP modulates depressive-like behaviors.[腺相关病毒，神经系统，皮层，干扰]
[5] Cell. (IF=28.71).Bian WJ,et.al.(2015).Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes.[腺相关病毒，神经]
[6] Cancer Discovery. (IF=19.783).Sun TT,et.al.(2016).A novel IncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern.[腺病毒，lncRNA，胃癌]
[7] Nature Neuroscience. (IF=16.724).Yang HB,et.al.(2015).Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.[腺相关病毒，光遗传]
[8] Nature Neuroscience. (IF=16.724).Zheng JJ,et.al.(2013).Oxytocin mediates early experience-dep Nature medicine endent cross-modal plasticity in the sensory cortices.[腺相关病毒，神经系统，感觉皮层]
[9] Cell Research. (IF=14.812).Xie C,et.al.(2016).Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome.[腺相关病毒，心脏应用]
[10] Cell Research. (IF=14.812).Gao M,et.al.(2014).Generation of transgenic golden Syrian hamsters.[慢病毒，转基因仓鼠]
[11] Nature Communications. (IF=11.329).Wei PF,et.al.(2015).Processing of visually evoked innate fear by a non-canonical thalamic pathway.[腺相关病毒，神经，丘脑]
[12] Nature Communications. (IF=11.329).Zhu YJ,et.al.(2015).Control of response reliability by parvalbumin-expressing interneurons in visual cortex.[腺相关病毒，视觉皮质]
[13] Nature Communications. (IF=11.329).Han G,et.al.(2016).Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice.[腺相关病毒，肌肉注射，基因ZL]
[14] Nature Communications. (IF=11.329).Yao XH,et.al.(2016).Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex.[慢病毒，神经系统，干扰]
[15] Embo Journal. (IF=9.643).Ren SQ,et.al.(2013).PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP.[腺相关病毒，神经系统，大脑皮层]
[16] Embo Molecular Medicine. (IF=9.547).Guan Y,et.al.(2016).CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse.[腺病毒，CRISPR/Cas9，血友病]
[17] PNAS. (IF=9.423).Li J,et.al.(2015).Synaptic P-Rex1 signaling regulates hippocampal longterm depression and autism-like social behavior.[腺病毒，体内感染]
[18] PNAS. (IF=9.423).Du H,et.al.(2016).Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding.[腺相关病毒，光遗传，大脑海马区域记忆]
[19] Developmental Cell. (IF=9.338).Cheng TL,et.al.(2014).MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex.[慢病毒，腺相关病毒，体内体外]
[20] Autophagy. (IF=9.108).Guo WJ,et.al.(2015).Small molecule-driven mitophagy-mediatedNLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer.[慢病毒，肿瘤细胞，干扰]
[21] Autophagy. (IF=9.108).Zhao XJ,et.al.(2015).Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancercells.[自噬]
[22] Diabetes. (IF=8.784).Xiao YZ,et.al.(2015).Activation of ERK1/2 ameliorates liver steatosis in leptin receptor deficient (db/db)mice via stimulating ATG7-dependent autophagy.[腺病毒，整体注射，肝脏]
[23] Clinical Cancer Research. (IF=8.738).Shi Y,et.al.(2014).Primate-specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma.[慢病毒，肿瘤细胞感染]
[24] Biomaterials. (IF=8.387).Luo X,et.al.(2015).CAD based design sensitivity analysis and shape optimization of scaffolds for bio-root regeneration in swine.[慢病毒，生物牙根研究]
[25] Biomaterials. (IF=8.387).Wang X,et.al.(2013).Promotion of dentin regeneration via CCN3 modulation on Notch and BMP signaling pathways.[慢病毒，牙髓干细胞，体外感染，基因表达与干扰]
[26] ELIFE. (IF=8.303).Chen M,et.al.(2015).Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation.[腺相关病毒，神经系统，腹侧被盖区]
[27] ELIFE. (IF=8.303).Ni KM,et.al.(2016).Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep.[腺相关病毒，丘脑]
[28] Oncogene. (IF=7.932).Wen SY,et.al.(2013).miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer.[慢病毒，肿瘤细胞，miRNA过表达]
[29] Cell Reports. (IF=7.87).Wang B,et.al.(2016).FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1.[腺相关病毒，背根神经节轴突，干扰]
[30] Redox Biology. (IF=6.235).Huang GY,et.al.(2016).Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons.[慢病毒，大鼠脊髓神经元，干扰]
[31] Diabetologia. (IF=6.206).Ma X,et.al.(2015).RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice.[腺相关病毒，肝脏，干扰]
[32] Cancer Letters. (IF=5.992).Fang ZY,et.al.(2016).A feed-forward regulatory loop between androgen receptor and PlncRNA-1 promotes prostate cancer progression.[CCK-8，Luciferase assay，前列腺癌细胞]
[33] Cancer Letters. (IF=5.992).Rao J,et.al.(2014).Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1.[慢病毒，肿瘤细胞，干扰]
[34] Journal of Neuroscience. (IF=5.924).Liu YG,et.al.(2015).Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.[腺相关病毒，神经系统]
[35] Free Radical Biology and Medicine. (IF=5.784).Cheng X,et.al.(2016).Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells.[质粒过表达，肺部]
[36] Aging Cell. (IF=5.76).Xiong YS,et.al.(2015).Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.[质粒，干扰]
[37] Mol Neurobiol. (IF=5.397).Hu G,et.al.(2016).Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.[慢病毒，神经元感染]
[38] Molecular Neurobiology. (IF=5.397).Guo J,et.al.(2015).Overexpression of Fibulin-5 Attenuates Ischemia/Reperfusion Injury After Middle Cerebral Artery Occlusion in Rats.[腺病毒，大鼠大脑中动脉]
[39] FASEB Journal. (IF=5.299).Wang Y,et.al.(2016).Down-regulation of Risa improves insulin sensitivity by enhancing autophagy.[腺病毒，小鼠原代肝细胞，过表达，自噬]
[40] Brain Pathology. (IF=5.256).Xu QF,et.al.(2014).MiR-22 is Frequently Down‐regulated in Medulloblastomas, and Inhibits Cell Proliferation via the Novel Target PAPST1.[慢病毒，肿瘤细胞感染]
[41] Scientific Reports. (IF=5.228).Xiong YS,et.al.(2015).Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion.[逆转录病毒，脑缺血，白质，认知障碍]
[42] Scientific Reports. (IF=5.228).Shan LL,et.al.(2015).Light exposure before learning improves memory consolidation at night.[腺相关病毒，海马，过表达]
[43] Scientific Reports. (IF=5.228).Tao Y,et.al.(2015).Astroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus.[腺相关病毒，胶质细胞]
[44] Scientific Reports. (IF=5.228).Gu Y,et.al.(2015).Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte.[慢病毒，MSC感染]
[45] Scientific Reports. (IF=5.228).Chen X,et.al.(2016).GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion.[慢病毒，神经系统，过表达，干扰]
[46] Scientific Reports. (IF=5.228).Lyu JW,et.al.(2016).Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.[慢病毒，神经系统，干扰]
[47] Scientific Reports. (IF=5.228).Zhu YB,et.al.(2016).Astrocyte-derived phosphatidic acid promotes dendritic branching.[慢病毒，星形胶质细胞，干扰]
[48] Scientific Reports. (IF=5.228).Yu X,et.al.(2016).Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin.[慢病毒，神经元感染]
[49] Scientific Reports. (IF=5.228).Zhu T,et.al.(2016).Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α.[慢病毒，腺相关病毒，光遗传]
[50] Scientific Reports. (IF=5.228).Wu GY,et.al.(2015).Optogenetic stimulation of mPFC pyramidal neurons as a conditioned stimulus supports associative learning in rats.[光遗传，腺相关病毒，前额叶皮质]
[51] Scientific Reports. (IF=5.228).Lv YF,et.al.(2015).Enhancer of zeste homolog2 silencing inhibits tumor growth and lung metastasis in osteosarcoma.[慢病毒，骨肉瘤，干扰]
[52] Breast Cancer Research. (IF=5.211).Li P,et.al.(2014).MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cellproliferation and migration.[细胞增殖，迁移]
[53] Frontiers in Molecular Neuroscience. (IF=5.154).Gao QQ,et.al.(2015).Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory.[腺相关病毒，杏仁核]
[54] Biochimica et Biophysica Acta-Molecular Cell Research. (IF=5.128).Xiang L,et.al.(2014).Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.[慢病毒，宫颈癌细胞，RNA干扰]
[55] Clinical Science. (IF=5.016).He T,et.al.(2015).Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis.[慢病毒，色素上皮衍生因子，干扰]
[56] Carcinogenesis. (IF=4.874).Zhu Z,et.al.(2014).Protein Tyrosine Phosphatase U (PTPRU) is Required for Glioma Growth and Motility.[慢病毒，肿瘤细胞]
[57] Journal of Neuroinflammation. (IF=4.667).Lin WP,et.al.(2016).Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury.[腺相关病毒，原代神经元]
[58] Cellular Physiology and Biochemistry. (IF=4.652).Zhou X,et.al.(2015).Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve Learning and Memory Function in Hypoxic-Ischemic Brain-Damaged Rats via an IL-8-Mediated Secretion Mechanism Rather than Differentiation Pattern Induction.[脐带来源间充质干细胞]
[59] Cellular Physiology and Biochemistry. (IF=4.652).Huo Y,et.al.(2015).Amino-Nogo Inhibits Optic Nerve Regeneration and Functional Recovery via the Integrin αv Signaling Pathway in Rats.[腺相关病毒，眼科应用]
[60] Frontiers in Cellular Neuroscience. (IF=4.609).Huang GH,et.al.(2016).Porf-2 inhibits neural stem cell proliferation through Wnt/β-catenin pathway by its GAP domain.[腺相关病毒，shRNA，mcherry，海马区域神经干细胞]
[61] Fertility and Sterility. (IF=4.426).Wang Y,et.al.(2015).MicroRNAome in decidua: a new approach to assess the maintenance of pregnancy.[慢病毒，人类胚胎干细胞，microRNA干扰]
[62] International Journal of Neuropsychopharmacology. (IF=4.333).Wang YX,et.al.(2014).Protein kinase Mζ is involved in the modulatory effect of fluoxetine on hippocampal neurogenesis in vitro.[腺相关病毒，海马，定位注射]
[63] Journal of Biological Chemistry. (IF=4.258).Tian T,et.al.(2013).Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery.[慢病毒，间充质干细胞]
[64] Journal of Biological Chemistry. (IF=4.258).Cai R,et.al.(2012).SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α.[腺相关病毒，心肌细胞感染]
[65] Journal of Biological Chemistry. (IF=4.258).Zhang B,et.al.(2016).Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity Dependent AMPA Receptor Trafficking.[腺相关病毒，小鼠海马神经元]
[66] International Journal of Biological Sciences. (IF=3.982).Li Y,et.al.(2016).Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats.[慢病毒，脑缺血]
[67] International Journal of Biological Sciences. (IF=3.982).Liu B,et.al.(2015).Gadd45b is a Novel Mediator of Neuronal Apoptosis inIschemic Stroke.[慢病毒，体内注射]
[68] International Journal of Biological Sciences. (IF=3.982).Kuang L,et.al.(2013).Knockdown of Nrf2 Inhibits the Angiogenesis of Rat Cardiac Micro-vascular Endothelial Cells under Hypoxic Conditions.[慢病毒，心肌血管内皮细胞，过表达]
[69] Cell Cycle. (IF=3.952).Meng ZS,et.al.(2015).Tumorigenicity Analysis of Heterogeneous Dental Stem Cells and Its Self-Modification for Chromosome Instability.[慢病毒，牙髓干细胞感染]
[70] Journal of Neurochemistry. (IF=3.842).Luo DJ,et.al.(2014).Knockdown of Phosphotyrosyl phosphatase activator (PTPA) induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation.[慢病毒，体外神经元细胞，过表达]
[71] Journal of Neurochemistry. (IF=3.842).Wang B,et.al.(2014).Destabilization of Survival Factor MEF2D mRNA by Neurotoxin in Models of Parkinson’s Disease.[腺相关病毒，脑黑质]
[72] Stem Cells International. (IF=3.687).Jia Q,et.al.(2016).The Regulatory Effects of Long Noncoding RNA-ANCR on Dental Tissue-Derived Stem Cells.[慢病毒，lncRNA干扰，牙齿组织来源的干细胞]
[73] Febs Letters. (IF=3.519).Li Q,et.al.(2013).MicroRNA-222 promotes tumorgenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway.[慢病毒，胶质瘤，microRNA表达]
[74] Journal of Vascular Surgery. (IF=3.454).Sun Y,et.al.(2016).The regulatory role of smooth muscle 22 on the proliferation of aortic smooth muscle cells participates in the development of aortic dissection.[慢病毒，主动脉平滑肌细胞，干扰]
[75] International Journal of Molecular Sciences. (IF=3.257).Qi SB,et.al.(2014).Validation of Bmi1 as a Therapeutic Target of HepatocellularCarcinoma in Mice.[慢病毒，细胞成瘤实验，干扰]
[76] Leukemia & Lymphoma. (IF=3.093).Yao CJ,et.al.(2014).The FA/BRCA pathway is involved in DNA interstrand cross-link repair of adriamycin-resistant leukemia cells.[慢病毒，肿瘤细胞]
[77] Plos One. (IF=3.057).Yang C,et.al.(2013).Systemic Blockade of Dopamine D2-Like Receptors Increases High-Voltage Spindles in the Globus Pallidus and Motor Cortex of Freely Moving Rats.[腺相关病毒，纹状体，定位注射]
[78] Plos One. (IF=3.057).Kuang CY,et.al.(2014).Schlafen 1 Inhibits the Proliferation and Tube Formation of Endothelial Progenitor Cells.[腺病毒，外周血内皮祖细胞，过表达]
[79] Plos One. (IF=3.057).Zeng J,et.al.(2014).GSK3β Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells.[慢病毒，非小细胞肺癌，基因表达]
[80] Plos One. (IF=3.057).Chen Y,et.al.(2016).Increased Expression of SETD7 Promotes Cell Proliferation by Regulating Cell Cycle and Indicates Poor Prognosis in Hepatocellular Carcinoma.[CCK-8]
[81] International Journal of Oncology. (IF=3.018).Lin X,et.al.(2015).Silencing of Livin inhibits tumorigenesis and metastasis via VEGF and MMPs pathway in lung cancer.[慢病毒，肺癌，干扰]
[82] Cell and Tissue Research. (IF=2.948).Han J,et.al.(2016).RhoB/ROCK mediates oxygen–glucose deprivation-stimulated syncytiotrophoblast microparticle shedding in preeclampsia.[慢病毒，绒毛膜癌细胞，过表达]
[83] Tumor Biology. (IF=2.926).Wang YP,et.al.(2016).Elevated OCT1 participates in colon tumorigenesis and independently predicts poor prognoses of colorectal cancer patients.[结肠直肠癌，干扰载体]
[84] Cancer Cell International. (IF=2.884).Jiang L,et.al.(2013).BAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer.[慢病毒包装，非小细胞肺癌细胞，过表达]
[85] Molecular Biosystems. (IF=2.829).Huang JC,et.al.(2015).microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.[慢病毒，microRNA]
[86] Immunobiology. (IF=2.781).Dai SL,et.al.(2016).Lentiviral vector encoding ubiquitinated hepatitis B core antigeninduces potent cellular immune responses and therapeutic immunityin HBV transgenic mice.[慢病毒,皮下注射,过表达]
[87] Journal of Neuro-Oncology. (IF=2.754).Zhu Z,et.al.(2013).ZFX regulates glioma cell proliferation and survival in vitro and in vivo.[慢病毒，胶质瘤，过表达]
[88] DNA and Cell Biology. (IF=2.574).Bai J,et.al.(2014).Inhibiting Enhancer of Zeste Homolog 2 Promotes Cellular Senescence in Gastric Cancer Cells SGC-7901 by Activation of p21 and p16.[慢病毒，晶状体内皮细胞，过表达]
[89] Brain Research. (IF=2.561).Lan WB,et.al.(2014).Overexpressing neuroglobin improves functional recovery by inhibiting neuronal apoptosis after spinal cord injury.[腺相关病毒，髓鞘注射感染脊髓，过表达]
[90] Brain Research. (IF=2.561).Li B,et.al.(2015).A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter.[腺相关病毒，体内,背根神经节]
[91] Experimental Biology and Medicine. (IF=2.542).Xu Y,et.al.(2016).Antitumor effects of galectin-3 inhibition in human.[人肾癌细胞，shRNA转染]
[92] Oncology Reports. (IF=2.486).Yang M,et.al.(2013).Knockdown of interferon-induced transmembrane protein 3 expression suppresses breast cancer cell growth and colony formation and affects the cell cycle.[慢病毒，乳腺癌细胞，RNA干扰]
[93] Genes and Immunity. (IF=2.472).Liang J,et.al.(2016).Downregulation of ZBTB24 hampers the G0/1- to S-phase cell-cycle transition via upregulating the expression of IRF-4 in human B cells.[慢病毒，干扰]
[94] Neurochemical Research. (IF=2.472).Huo Y,et.al.(2013).Inhibition of Retinal Ganglion Cell Axonal Outgrowth Through the Amino-Nogo-A Signaling Pathway.[腺相关病毒，视网膜注射感染神经节细胞，过表达]
[95] Biochemical and Biophysical Research Communications. (IF=2.371).Ma B,et.al.(2014).TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.[慢病毒，晶状体内皮细胞，过表达]
[96] Biochemical and Biophysical Research Communications. (IF=2.371).Liu ZQ,et.al.(2016).Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p.[lncRNA，luciferase，靶基因验证]
[97] Journal of Molecular Neuroscience. (IF=2.352).Zhang P,et.al.(2013).Protocadherin 11 X Regulates Differentiation and Proliferation of Neural Stem Cell In Vitro and In Vivo.[慢病毒，神经干细胞]
[98] Biomed Research International. (IF=2.134).Guo S,et.al.(2014).Optogenetic Activation of the Excitatory Neurons Expressing CaMKIIα in the Ventral Tegmental Area Upregulates the Locomotor Activity of Free Behaving Rats.[腺相关病毒，大脑皮层，定位注射]
[99] Acta Biochim Biophys Sin. (IF=2.124).Dai S,et.al.(2015).Dendritic cell-based vaccination with lentiviral vectors encoding ubiquitinated hepatitis B core antigen enhances hepatitis B virus-specific immune responses in vivo.[慢病毒，DC细胞感染]
[100] Neuroscience Letters. (IF=2.107).Fan LF,et.al.(2013).Caspr interaction with Amyloid Precursor Protein reduces amyloid-β generation in vitro.[慢病毒，体外神经元细胞，RNA干扰]
[101] International Journal of Environmental Research and Public Health. (IF=2.035).Wang X,et.al.(2015).Blocking the Wnt/β-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting β-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice.[慢病毒，肺部，干扰]
[102] Archives of Oral Biology. (IF=1.733).Jia Q,et.al.(2015).Down-regulated non-coding RNA (lncRNA-ANCR) promotes osteogenic differentiation of periodontal ligament stem cells.[慢病毒，牙周膜肝细胞，成骨分化，干扰]
[103] Immunopharmacology and Immunotoxicology. (IF=1.617).Bai D,et.al.(2015).Cytotoxic T lymphocyte antigen 4 decreases humoral and cellular immunity by adenovirus to enhance target GFP gene transfer in C57BL/6 mice.[腺病毒，体内感染]
[104] IJCEP. (IF=1.581).Ma ZY,et.al.(2013).Knocking down SMC1A inhibits growth and leads to G2/M arrest in human glioma cells.[慢病毒，肿瘤细胞，RNA干扰]
[105] International Journal of Clinical and Experimental Pathology. (IF=1.581).Chen YS,et.al.(2012).Local injection of lentivirus-delivered livin shRNA suppresses lung adenocarcinoma growth by inducing a G0/G1 phase cell cycle arrest.[慢病毒，肺腺癌细胞，RNA干扰]
[106] International Journal of Clinical and Experimental Pathology. (IF=1.581).Liu YJ,et.al.(2014).Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.[慢病毒，肿瘤细胞，干扰]
[107] Molecular Medicine Reports. (IF=1.559).Wu YH,et.al.(2015).c-Jun N-terminal kinase inhibitor favors transforming growth factor‑β to antagonize hepatitis B virus X protein‑induced cell growth promotion in hepatocellular carcinoma.[慢病毒，肝癌细胞，过表达]
[108] Molecular Medicine Reports. (IF=1.559).Qu Z,et.al.(2016).Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells.[SCG-7901人胃癌细胞，MCF-7人乳腺癌细胞]
[109] Molecular Medicine Reports. (IF=1.559).Gua HP,et.al.(2016).Effects of RNA interference-mediated knockdown of livin and survivin using monomethoxypolyethylene glycol-chitosan nanoparticles in MG-63 osteosarcoma cells.[质粒，骨肉瘤细胞，干扰]
[110] Tohoku Journal of Experimental Medicine. (IF=1.287).Hong Z,et.al.(2016).Airborne Fine Particulate Matter Induces Oxidative Stress and Inflammation in Human Nasal Epithelial Cells.[CCK-8]
[111] J Huazhong Univ Sci Technol. (IF=0.838). Luo HB ,et.al.(2015).Knockdown of Bmi1 Inhibits Bladder Cancer Cell Growth Both In Vitro and In Vivo by Blocking Cell Cycle at G1 Phase and Inducing Apoptosis.[慢病毒，EJ膀胱癌细胞，干扰]
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