Cystatin-M / Cystatin-E / CST6抗体产品信息
免疫原 :
Recombinant human CST6 protein ( Catalog#10438-H08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
4E7C10B7
抗体宿主 :
Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Cystatin-M / CST6 ( rh Cystatin-M ; Catalog#10438-H08H ; NP_001314.1 ; Met 1 - Met 149 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Cystatin-M / Cystatin-E / CST6抗体背景综述
Cystatin-M / Cystatin-E, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and Cathepsin-B. Cystatin-E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of Cystatin-M / Cystatin-E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, Cystatin-M / Cystatin-E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that Cystatin-M / Cystatin-E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.
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