本公司提供科研phospho-MBP(Tyr203)磷酸化髓鞘碱性蛋白抗体，抗体质量可靠，订购phospho-MBP(Tyr203)磷酸化髓鞘碱性蛋白抗体请联系在线客服或者销售人员。 抗体参数如下>>>> 中文名称：磷酸化髓鞘碱性蛋白抗体 英文名称：Anti-phospho-MBP(Tyr203) 货号：bs-5475R 抗体来源：兔 克隆类型：多克隆 蛋白分子量：predicted molecular weight: 33kDa 纯化方法：affinity purified by Protein A 交叉反应：hu, dog 测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 产品背景介绍：Oligodendrocyte Marker The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Subunit : Homodimer. Isoform 3 exists as a homodimer.Subcellular Location : Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.Tissue Specificity : MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.Similarity : Belongs to the myelin basic protein family.少突胶质细胞标志物。 主要用于脊髓脱髓鞘病-脊髓多发硬化症的研究。 MBP髓鞘碱性蛋白和髓鞘相伴糖蛋白是多发性硬化的自身免疫攻击的靶。
