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phospho-NFATc2(Ser326)磷酸化核因子活化T细胞胞浆蛋白2抗体，抗体质量可靠，订购
phospho-NFATc2(Ser326)磷酸化核因子活化T细胞胞浆蛋白2抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
磷酸化核因子活化T细胞胞浆蛋白2抗体英文名称：
Anti-phospho-NFATc2(Ser326)货号：bs-2669R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, hrs, pig, cow, dog, chk, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.Subunit : Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP.Subcellular Location : Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.Tissue Specificity : "Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas.Similarity : Contains 1 RHD (Rel-like) domain
