Anti-phospho-NFATc2(Ser326)磷酸化核因子活化T细胞胞浆蛋白2抗体

本公司经销phospho-NFATc2（Ser326），磷酸化核因子活化T细胞胞浆蛋白2抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-NFATc2（Ser326）磷酸化核因子活化T细胞胞浆蛋白2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2669R
英文名称：Anti-phospho-NFATc2（Ser326）
中文名称：磷酸化核因子活化T细胞胞浆蛋白2抗体
其他名称：名AI607462; KIAA0611; NF ATp; NF-ATc2; NFAT 1; NFAT pre existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFAT1-D; NFATc2; NFATp; Nuclear factor of activated T cells cytoplasmic 2; Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2; Nuclear factor of activated T cells pre-existing component; T cell transcription factor NFAT.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, hrs, pig, cow, dog, chk, mo, rat
产品介绍：Nuclear factor of activated T cells （NFAT） is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy ａnd adipocyte differentiation. NFAT1 （also known as NFATc2 or NFATp） is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus ａnd activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.Subunit : Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 ａnd an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 ａnd Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP.Subcellular Location : Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form ａnd nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained ａnd transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.Tissue Specificity : "Expressed in thymus, spleen, heart, testis, brain, placenta, muscle ａnd pancreas.Similarity : Contains 1 RHD （Rel-like） domain