| 规格： | 250 U | 产品价格： | ￥2268 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2268 |
| 分子量(MW): | 454.86 | |
|---|---|---|
| 化学式: | C22H19ClN4O5 | |
| 溶解度: | DMSO ≥39mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 475108-18-0 |
Tivozanib (AV-951) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively. Tivozanib (AV-951) has potential antiangiogenic and antineoplastic activities. Tivozanib (AV-951) inhibits c-Kit and PDGFR at 10-times higher concentrations. Tivozanib (AV-951) is a novel oral quinoline urea derivative. Preclinical data indicate that AV-951 blocks the proliferation and migration of endothelial cells in vitro, and suppresses angiogenesis and growth of human tumor xenografts in vivo. Tivozanib has been shown to be safe and orally bioavailable when given to cancer patients. Tivozanib (AV-951) is under early clinical investigation for the treatment of renal cell carcinoma and non-small cell lung carcinoma, as well as in combination with other chemotherapies in breast, colorectal, and other gastrointestinal cancer patients. [1]
特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。
