| 规格： | 5 mg | 产品价格： | ￥1323 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥1323 |
| 分子量(MW): | 377.35 | |
|---|---|---|
| 化学式: | C19H13F2N7 | |
| 溶解度: | DMSO ≥76mg/mL Water <1mg/mL Ethanol ≥2mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 943540-75-8 |
JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and 50 nmol/L, respectively. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo. [1]
| After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of JNJ-38877605 for 3h,followed by 15-minute stimolation of 100ng/ml EGF
| |
| Inducers of EMT. (A) Expression of Hgf, Egf, and Tgfb1 genes in RETAAD tumors analyzed by qRT-PCR. Hgf and Tgfb1 are preferentially expressed in PMN-MDSC, while Egf is preferentially expressed in tumor cells. Data are from four individual experiments using sorted fractions of PMNMDSC and melanoma cells. Bars represent mean 6 SD. (B) NBT-II cells (100 cells per well) were plated for 4 d to allow for colony growth and were pretreated for 24 h with inhibitors before the addition of PMN-MDSC. After co-culture with PMN-MDSCs in the presence of inhibitors, cells were fixed and stained with anti-rat desmoplakin. Green, Desmoplakin; red, H2b (nuclear stain). PD153035 – EGFR inhibitor, JNJ38877605 – c-met (HGFR) inhibitor, and SB525334 – TGF-bR1 inhibitor. Images are representative of three independent experiments. |
特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。
