现货，ABT-737，selleck，美国进口，Bcl-2 YZ剂，CAS号: 852808-04-9 ，目录号：S1002_详细资料

规格：	48T	产品价格：	￥2268
规格：	5mg	产品价格：	￥2268

规格：

48T

产品价格：

￥2268

规格：

5mg

产品价格：

￥2268

分子量(MW):	813.43
化学式:	C₄₂H₄₅ClN₆O₅S₂
溶解度:	DMSO ≥163mg/mL Water <1mg/mL Ethanol <1mg/mL
纯度:	>99%
稳定性:	at -20℃ 2 years
CAS号:	852808-04-9

分子量(MW):

813.43

化学式:

C₄₂H₄₅ClN₆O₅S₂

溶解度:

DMSO ≥163mg/mL Water <1mg/mL Ethanol <1mg/mL

纯度:

>99%

稳定性:

at -20℃ 2 years

CAS号:

852808-04-9

	Effect of ABT-737 on the cell viability of CCRF-CEM cells by treatments of AY4 (10 lg/ml), TRAIL (0.5 lg/ml), SAHA (1 lM),VPA (1 mM), or ABT-737 (10 lM) alone or in combination for 24 h prior to MTT assay.
	Upper panel ABT-737 inhibits TFK-1 and EGI-1 cell growth.Cells were exposed to ABT-737 at a concentration ranging from 1 to 50 lM. Following 72 h of incubation, growth inhibition was analyzed by crystal violet assay. Dose–effect plot of ABT-737 treatment is presented.
	Lower panel detection of PARP-1, cleaved caspase-9 and caspase-3, BCL-2 and MCL-1 in TFK-1 and EGI-1 cells after 72 h of ABT-737 treatment (1, 3, 10, 25,50 lM). Cell lysates were analyzed on Western blotting.
	3 mM ABT737 inhibited growth and viability of TF-1 cells and potentiated proapoptotic effects of 1 mM BIO after 72 hours treatment. TF-1 cells treated with both drugs exhibited more apoptotic cells compared to those treated with each single drug. ABT737 abrogated the protection from BIO-induced apoptosis provided by MS5 coculture.
	BCL-XL mediates human neutrophil survival. PMNs were preincubated with the BH3 mimetic ABT-737 (1–10 μM), then cultured in normoxia (gray bars) with or without GM-CSF (500 U/ml) or hypoxia (white bars)or 20 hours, and apoptosis was assessed by morphology (n = 4).
	Bcl-XL/Bcl-2 inhibitor ABT-737 aggravates the proapoptotic effects of IL-1IFN-. INS-1E cells were transfected with single or smart Pool PUMA siRNAs and exposed to ABT-737 for 24 h. At this time point, cell death was measured by HO/PI, n 3. , p 0.05; *, p 0.01.
	MEF wt and MEF Mcl-1 ko mice activating active caspase-3 using 1um ABT for 24h
	MDB-MA-231 cells were exposed to 30 um cisplatin in the absence or in thepresence of 100nm ABT-737.The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

Effect of ABT-737 on the cell viability of CCRF-CEM cells by treatments of AY4 (10 lg/ml), TRAIL (0.5 lg/ml), SAHA (1 lM),VPA (1 mM), or ABT-737 (10 lM) alone or in combination for 24 h prior to MTT assay.

Upper panel ABT-737 inhibits TFK-1 and EGI-1 cell growth.Cells were exposed to ABT-737 at a concentration ranging from 1 to 50 lM. Following 72 h of incubation, growth inhibition was analyzed by crystal violet assay. Dose–effect plot of ABT-737 treatment is presented.

Lower panel detection of PARP-1, cleaved caspase-9 and caspase-3, BCL-2 and MCL-1 in TFK-1 and EGI-1 cells after 72 h of ABT-737 treatment (1, 3, 10, 25,50 lM). Cell lysates were analyzed on Western blotting.

3 mM ABT737 inhibited growth and viability of TF-1 cells and potentiated proapoptotic effects of 1 mM BIO after 72 hours treatment. TF-1 cells treated with both drugs exhibited more apoptotic cells compared to those treated with each single drug. ABT737 abrogated the protection from BIO-induced apoptosis provided by MS5 coculture.

BCL-XL mediates human neutrophil survival. PMNs were preincubated with the BH3 mimetic ABT-737 (1–10 μM), then cultured in normoxia (gray bars) with or without GM-CSF (500 U/ml) or hypoxia (white bars)or 20 hours, and apoptosis was assessed by morphology (n = 4).

Bcl-XL/Bcl-2 inhibitor ABT-737 aggravates the proapoptotic effects of IL-1IFN-. INS-1E cells were transfected with single or smart Pool PUMA siRNAs and exposed to ABT-737 for 24 h. At this time point, cell death was measured by HO/PI, n 3. *, p 0.05; **, p 0.01.

MEF wt and MEF Mcl-1 ko mice activating active caspase-3 using 1um ABT for 24h

MDB-MA-231 cells were exposed to 30 um cisplatin in the absence or in thepresence of 100nm ABT-737.The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

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