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Octamer-4 (Oct4), a homeodomain transcription factor of the POU family (POU5F1) is involved in regulation of pluripotency during normal development. The expression of Oct4 is associated with an undifferentiated phenotype in embryonic stem (ES) cells, while gene knockdown of Oct4 promotes differentiation. As such, it is frequently used as a marker for undifferentiated ES cells or iPS (induced pluripotent stem) cells. Oct4 is one of the four key transcription factors (Oct4, Sox2, c-Myc, and Klf4) used to reprogram mouse and human fibroblasts to a pluripotent state.1-5
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