CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor
that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface
components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and
have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune
response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single
carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor
tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells.
CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in
inflammation.
Product Info
Amount : 25 μg / 100 μg
Purification : Protein G Chromatography
Content :
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium
azide is highly toxic.
Storage condition :
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid
repeated freeze and thaw cycles.
