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 血管新生部分重组蛋白0049-JAG1RecombinantProtein(Q01)

产品信息
  • Gene Information

     
    Gene Name:
    JAG1 
    Related Disease:
    arteriohepatic dysplasia, cholestasis with peripheral pulmonary stenosis, syndromatic hepatic ductular hypoplasia

    Gene Pathway
    Notch signaling pathway

     
    Gene Description:
    jagged 1 (Alagille syndrome)
     
     
    Gene Alias:
    AGS, AHD, AWS, HJ1, JAGL1, MGC104644 
     
    Entrez GeneID:
    182 
     
    Omim ID:
    118450 187500 601920
     
     
    Protein Accession#:
    NP_000205 
     
    Gene Ontology:
    Hyperlink 
     

    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

     Product Information

     
    Product Description:
    JAG1( NP_000205, 531 a.a. - 621 a.a.) partial recombinant protein with GST.
       
     
    Protein Sequence:
    PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLK
    DHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNV
    CGPHGKCKSQSGGKFTCDCNKG*
     
    Molecular Weight:
    36.01 kDa
       
     
    Polypeptide Chain:
    Human JAG1
       
     
    Length with Tag:
    324 aa with GST tag
       
     
    Storage Buffer:
    50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
       
    Storage Instruction:
    Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
      
    Quality Control Testing:
    12.5% SDS-PAGE Stained with Coomassie Blue
      
    Note:Best use within one month from the date of receipt of this protein.
    温馨提示:不可用于临床ZL。
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