产品编号:
200-06
别名:
26 kDa protein,IFN-β2,B cell differentiation factor （BCDF）,BSF-2,HPGF,HSF,MGI-2
描述:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune ａnd inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells ａnd keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation ａnd antibody production, synergizes with IL-3 in megakaryocyte development ａnd platelet production, induces expression of hepatic acute-phase proteins, ａnd regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α ａnd gp130. Murine IL-6 is inactive on human cells, while both human ａnd murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
氨基酸序列:
PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107units/mg.
交叉反应:
Monkey, Mouse, Rat
研究领域:
 | 血管生成/ 心血管 |  | 癌症 |
 | 细胞培养 |  | 糖尿病/ 体重调节 |
 | 免疫系统 |  | 炎症 |
 | 神经生物学 |  | 干细胞及分化 |
 | 创伤修复 |  | 过敏 |
 | 移植 | | |
原产国:
USA
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