特价 Recombinant Murine FGF-basic 价格
Catalog Number:
450-33
Synonyms:
Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin
Description:
FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development ａnd postnatal growth ａnd regeneration of a variety of tissues, by promoting cellular proliferation ａnd differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells ａnd endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c ａnd 4. Recombinant murine FGF-basic is a 16.3 kDa protein consisting of 145 amino acid residues.
AA Sequence:
PALPEDGGAA FPPGHFKDPK RLYCKNGGFF LRIHPDGRVD GVREKSDPHV KLQLQAEERG VVSIKGVCAN RYLAMKEDGR LLASKCVTEE CFFFERLESN NYNTYRSRKY SSWYVALKRT GQYKLGSKTG PGQKAILFLP MSAKS
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.1 ng/ml corresponding to a specific activity of ≥ 1 x 107units/mg.
Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Cross Reactivity:
Rabbit, Mouse, Rat, Human
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