PRO-781 PHLDA2 Human/重组人普列克底物蛋白同系物样家族A成员2
- 产地：美洲
- 供应商：厦门慧嘉生物科技有限公司
- 供应商报价：电议
- 标签：PRO-781 PHLDA2 Human/重组人普列克底物蛋白同系物样家族A成员2,生物试剂,生化试剂,供应PRO-781 PHLDA2 Human/重组人普列克底物蛋白同系物样家族A成员2,厦门慧嘉生物科技有限公司
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| Synonyms | Pleckstrin homology-like domain family A member 2, Imprinted in placenta ａnd liver protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, Tumor-suppressing STF cDNA 3 protein, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, p17-Beckwith-Wiedemann region 1 C, PHLDA2, BWR1C, HLDA2, IPL, TSSC3, BRW1C. |
| Introduction | Pleckstrin homology-like domain family A member 2 （PHLDA2） is a cytoplasmic protein, which is involved in fetal ａnd placental growth. PHLDA2 is an apoptosis-related protein, which acts as a negative growth regulator ａnd is expressed during normal human development. PHLDA2 is imprinted on placenta, liver ａnd fetal tissues during embryogenesis ａnd is removed once development is complete. The PHLDA2 gene is one of a number of genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Changes in this region may be linked to the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, ａnd lung, ovarian, ａnd breast cancer. PHLDA2 is expressed in placenta （present in all cells of the villous cytotrophoblast） ａnd adult prostate gland. Furthermore, PHLDA2 is expressed in adult brain ａnd neuroblastoma, medullablastoma ａnd glioblastoma cell lines ａnd at low levels in adult liver ａnd lung, ａnd fetal liver. |
| Description | PHLDA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids （1-152 a.a.） ａnd having a molecular mass of 19.2 kDa. PHLDA2 is fused to 20 amino acid His Tag at N-terminus ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | PHLDA2 solution containing 20mM Tris-HCl buffer （pH8.0）, 20% glycerol 0.1M NaCl ａnd 1mM DTT. |
| Stability | PHLDA2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity | Greater than 80% as determined by SDS-PAGE. |
| Amino acid sequence | MGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
