产品库

重组人脑Ras同系物/RHEB Human

产品信息
重组人脑Ras同系物/RHEB Human
产品编号:PRO-308
产品规格:10μg/50μg/1mg
Catalogue NumberPRO-308
Synonyms RHEB2, GTP-binding protein Rheb, MGC111559, Ras homolog enriched in brain, RHEB.
Introduction RHEB is part of the Ras & GTPase superfamily that was originally identified as an immediate-early gene in brain but is also widely expressed in other tissues. RHEB encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is necessary in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. RHEB induces oncogenic transformation. RHEB overexpression accelerates lymphomagenesis and is associated with prostate cancer. RHEB can cytopathologically distinguish between fibroadenoma from malignant breast carcinomas which is considered as a secondary diagnostic tool. RHEB has a central role in the regulation of the Ras/B-Raf/C-Raf/MEK signaling network.
Description RHEB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids (1-181 amino acids) and having a molecular mass of 21.7 kDa.

The RHEB is fused to T7-tag at N-terminus (16 a.a.) and is purified by standard chromatography techniques.
Source Escherichia Coli.
Physical Appearance Sterile Filtered colorless solution.
Formulation The RHEB protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
Stability Store at 4°C if entire vial will be used within 2-4 weeks.

Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Avoid multiple freeze-thaw cycles.
Amino Acid Sequence MASMTGGQQM GRGSASMPQS KSRKIAILGY RSVGKSSLTI QFVEGQFVDS YDPTIENTFT KLITVNGQEY HLQLVDTAGQ DEYSIFPQTY SIDINGYILV YSVTSIKSFE VIKVIHGKLL DMVGKVQIPI MLVGNKKDLH MERVISYEEG KALAESWNAA FLESSAKENQ TAVDVFRRII LEAEKMDGAA SQGKSSC.
Purity Greater than 95.0% as determined by SDS-PAGE.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
信息声明:本产品供应信息由仪器网为您整合,供应商为(厦门慧嘉生物科技有限公司),内容包括 ( 重组人脑Ras同系物/RHEB Human)的品牌、型号、技术参数、详细介绍等;如果您想了解更多关于 ( 重组人脑Ras同系物/RHEB Human)的信息,请直接联系供应商,给供应商留言!
供应商产品推荐
    您可能感兴趣的产品