人结合珠蛋白/Haptoglobin Human
- 产地：福建 厦门市
- 供应商：厦门慧嘉生物科技有限公司
- 供应商报价： 电议
- 标签：人结合珠蛋白/Haptoglobin Human,人结合珠蛋白/Haptoglobin Human价格,人结合珠蛋白/Haptoglobin Human厂家
产品库
| Catalogue Number | PRO-558 |
| Synonyms | Haptoglobin, HP, BP, HPA1S, MGC111141, HP2-ALPHA-2. |
| Introduction | Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two a- and two b-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist (Hp 1-1, Hp 2-1, and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, and Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa. Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also |
| De | Human Haptoglobin produced from pooled human plasma corresponding to the Mw of isotypes of Haptoglobin at 86kD and >200kD. |
| Source | Pooled human plasma. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts. |
| Stability | Human Haptoglobin although stable at room temperature for 3 weeks, should be stored between 2-8°C. |
| Purity | Greater than 96.0%. |
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
