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重组人细胞周期蛋白依赖型激酶2联系蛋白1/ CDK2AP1 Human

产品信息
重组人细胞周期蛋白依赖型激酶2联系蛋白1/ CDK2AP1 Human
产品编号：PKA-362
产品规格：5μg/25μg/1mg
 
Catalogue NumberPKA-362
Synonyms Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Putative oral cancer suppressor, deleted in oral cancer 1, DOC-1, CDK2AP1, CDKAP1, DOC1, ST19, DORC1, p12DOC-1.
Introduction CDK2AP1 is a CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP1 interacts with DNA polymerase alpha and mediates the phosphorylation of the large p180 subunit, which implicates the regulatory role in DNA replication during S phase of the cell cycle.
Description CDK2AP1 Human Recombinant fused to 37 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 152 amino acids (1-115 a.a.) and having a molecular mass of 16.6 kDa. The CDK2AP1 is purified by proprietary chromatographic techniques.
Source Escherichia Coli.
Physical Appearance Sterile Filtered clear colorless solution.
Formulation The CDK2AP1 solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol.
Stability CDK2AP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
Amino acid sequence RGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS.
Purity Greater than 95.0% as determined by SDS-PAGE.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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