Cefsulodin sodium/头孢磺吡苄钠
产品编号：C058
产品规格：1g/5g
| CAS Number | 52152-93-9 |
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| Molecular Formula | C22H19N4NaO8S2 · xH2O |
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| Molecular Weight | 554.53 (Anhydrous basis) g/mol |
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| Form | Powder |
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| Appearance | White or yellow crystalline powder |
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| Purity Level | ≥97.0% |
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| Solubility | Water: Freely soluble |
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| Source | Synthetic |
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| Water Content (Karl Fisher) | 5.0% |
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| pH | 3.3-4.8 |
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| Melting Point | 175 °C |
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| Storage Conditions | -20 °C. |
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Description
Cefsulodin sodium is a third generation cephalosporin antibiotic.
Recently, TOKU-E has found that the main cause of cefsulodin instability stems from one key impurity in 7-ACA (7-aminocephalosporanic acid- a raw material used in the synthesis of cefsulodin). In order to produce high-purity, high-stability cefsulodin, TOKU-E uses industrial HPLC to remove significant quantities of this impurity in 7-ACA and thus produce ultra-pure, ultra-stable, and ultra-potent cefsulodin.
Mechanism
like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
>Cefsulodin sodium has a very limited spectrum specifically targeting Pseudomonas aeruginosa. Other members of the gram positive and gram negative species show little susceptibility.
Microbiology Applications
Cefsulodin sodium is commonly used in clinical in vi
