T027 Ticarcillin disodium/替卡西林钠

Ticarcillin disodium/替卡西林钠
产品编号：T027 
产品规格：1g

CAS Number	4697-14-7
Molecular Formula	C15H14N2Na2O6S2
Molecular Weight	428.39 g/mol
Form	Powder
Appearance	Creamy-white hygroscopic non-crystalline powder
Purity Level	≥99.0%
Solubility	Water: Freely soluble
Source	Semi-synthetic
Water Content (Karl Fisher)	<6.0%
pH	6.0-8.0
Boiling Point	768.3 °C
Melting Point	252.6 °C
Flash Point	418.4 °C
Optical Rotation	+172° to +187°
Storage Conditions	2-8 °C

Description
Ticarcillin disodium is an extended spectrum β-lactam in the carboxypenicillin family.
TOKU-E offers two forms of ticarcillin disodium: ticarcillin disodium (T027) and ticarcillin disodium w/clavulanate potassium (T020). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
Ticarcillin disodium is a broad spectrum antibiotic targeting a wide range of Gram positive and gram negative organisms.
Microbiology Applications
Ticarcillin disodium is commonly used in clinical in vitro microbiolo